What are knockout mice primarily used for in research?

Knockout mice are primarily utilized in research to study gene function by selectively removing specific genes from their genomes. This genetic modification allows researchers to observe the resulting physiological and phenotypic changes that occur in the organism due to the absence of that particular gene. By comparing knockout mice with normal (wild-type) mice, scientists can gain valuable insights into the role and importance of specific genes in development, metabolism, disease processes, and overall biology.

This approach is crucial in understanding genetic contributions to health and disease, as it can help identify gene functions that may be involved in various conditions, including cancer, heart disease, and genetic disorders. The use of knockout mice provides a powerful tool for elucidating the mechanisms of gene action and exploring potential therapeutic targets for drug development.